布洛芬是临床上常用的非甾体抗炎药,用于解热和镇痛治疗。作为经常占据用药助手搜索榜前三的药物,今天用药君就来讲一讲布洛芬与其他药物的相互作用和配伍禁忌!
一、与阿司匹林合用
阿司匹林与布洛芬合用,可增加胃肠毒性(如溃疡、出血),并可干扰低剂量阿司匹林对血小板的不可逆抑制作用而影响阿司匹林预防心血管事件的效应,还可显著降低布洛芬血清水平[1]。
2015 年 FDA 曾发布警示:在使用非甾体抗炎药(NSAIDs)的最初数周内,就存在心脏病发作或脑卒中的风险,这两种风险均可导致死亡。使用时间越长,风险越大;剂量越高,风险也越大。
处理措施:应避免合用。在给予阿司匹林速释制剂前至少 8 小时或 30 分钟后使用布洛芬可能减轻对阿司匹林不可逆抑制血小板的影响。
二、与噻嗪类利尿剂合用
参考文献
[1] Gengo FM,Rubin L,Robson M,et al.Effects of ibuprofen on the magnitude and duration of aspirin's inhibition of platelet aggregation:clinical consequences in stroke prophylaxis.J Clin Pharmacol,2008,48(1):117-122.
[2] Knauf H, Bailey MA, Hasenfuss G et al: The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects. Eur J Clin Pharmacol (2006) 62 (11/Nov): 885-92.
[3] Cheetham TC, Levy G, Niu Fet al: Gastrointestinal safety of nonsteroidal antiinflammatory drugs andselective cyclooxygenase-2 inhibitors in patients on warfarin. Ann Pharmacother(2009) 43 (11/Nov): 1765-73
[4]Weil J, Langman MJ, Wainwright P et al: Peptic ulcer bleeding: accessory risk factors and interactions with non-steroidal anti-inflammatory drugs. Gut (2000) 46 (1/Jan): 27-31
[5]MedicinesComplete: Baxter K (ed). Aminoglycosides NSAIDs: Stockleys Drug Interactions. RPS Publishing, London, UK, Available from URL: http://www.medicinescomplete.com/mc [Accessed on 10/07/2008]
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