一项新的研究表示，过高的血糖水平会增加心脏疾病患者的并发症风险。
研究表明，高血糖（葡萄糖）会导致血管强烈收缩，这可能与一种蛋白质有关。该研究可能提示一种针对心脏疾病和脑卒中的全新治疗方法，有助改善其预后。
英国莱斯特大学的研究人员表示，当心脏的供血血管受阻，就会发生心脏疾病。在发生心脏疾病时，高血糖会使血管收缩，加重阻塞，增加并发症风险。
心血管细胞生理学讲师Richard Rainbow在一所大学的新闻发布会上表示，「我们发现，血液中糖（葡萄糖）的量会改变血管的生理状态，使其比正常情况下收缩更强烈。继而导致血压增高，重要器官供血减少。」
「这是一项实验室研究，因此关于此现象发生的原因和产生的影响，我们在可控的条件下得出了结论。」
「我们发现，著名的信号蛋白家族—蛋白激酶C在这种收缩效应中起关键作用，并且我们可以通过抑制这些蛋白，使收缩的血管恢复正常水平，减少对心脏的影响。」
Rainbow表示，「这是首次在葡萄糖对血管收缩的作用上，以及对这种收缩效应的可能机制上给出直接证据的研究。我们在这次研究中使用的实验模型包括人类血管，和通过大量进食达到的高血糖水平，进而改变血管的收缩状态。」
「许多心脏疾病患者由于应激反应，会产生很多葡萄糖。这意味着即使不患有糖尿病，心脏疾病患者也会发生高血糖。」
本文被发表在最新的在线《英国药理学杂志》（British Journal of Pharmacology）上。
High blood sugar levels can increase the risk of complications in heart attack patients, a new study suggests.
Researchers found that high blood sugar (glucose) causes stronger contraction of blood vessels and also identified a protein associated with this increased contraction. The findings could lead to new treatments to improve outcomes after heart attack or stroke, the study authors said.
A heart attack occurs when an artery that provides blood to the heart is blocked. High blood sugar at the time of a heart attack could make this blockage more severe by causing the artery to contract, resulting in a higher risk of complications, according to the research team at the University of Leicester in England.
'We have shown that the amount of sugar, or glucose, in the blood changes the behavior of blood vessels, making them contract more than normal. This could result in higher blood pressure, or could reduce the amount of blood that flows through vital organs,' Richard Rainbow, a lecturer in cardiovascular cell physiology, said in a university news release.
'This was an experimental lab study, which means that we can draw conclusions about cause and effect in a controlled environment,' he added.
'Here, we have identified a known signaling protein family, protein kinase C, is a key part of this enhanced contractile response, and have also shown in our experiments that we can restore the normal level of contractile response and reverse the effects on the heart, with inhibitors of these proteins,' Rainbow said.
'This is the first study to show direct evidence of blood vessel contraction to glucose, and the potential mechanism behind this contractile response. In the experimental models we used in this study, including human blood vessels, increasing glucose to the levels that could be reached after a large meal altered vascular contraction,' Rainbow said.
'A large number of people who suffer a heart attack will have high glucose due to the 'stress response'. This means that even people who are not diabetic may [have high blood sugar] during a heart attack,' he explained.
The study was published online recently in the British Journal of Pharmacology.
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