Cell子刊：巨噬细胞中的Dectin

Cell Reports

[IF:7.815]

Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response

巨噬细胞的C型凝集素受体——Dectin-1及甘露糖受体在肠道炎症反应中的不同作用

10.1016/j.celrep.2020.03.018

03-31, Article

Abstract & Authors:

Abstract:
Colonic macrophages are considered to be major effectors of inflammatory bowel diseases (IBDs) and the control of gut inflammation through C-type lectin receptors is an emerging concept. We show that during colitis, the loss of dectin-1 on myeloid cells prevents intestinal inflammation, while the lack of mannose receptor (MR) exacerbates it. A marked increase in dectin-1 expression in dextran sulfate sodium (DSS)-exposed MR-deficient mice supports the critical contribution of dectin-1 to colitis outcome. Dectin-1 is crucial for Ly6ChighCCR2high monocyte population enrichment in the blood and their recruitment to inflamed colon as precursors of inflammatory macrophages. Dectin-1 also promotes inflammasome-dependent interleukin-1β (IL-1β) secretion through leukotriene B4 production. Interestingly, colonic inflammation is associated with a concomitant overexpression of dectin-1/CCL2/LTA4H and downregulation of MR on macrophages from IBD patients. Thus, MR and dectin-1 on macrophages are important mucosal inflammatory regulators that contribute to the intestinal inflammation.

First Authors:
Mouna Rahabi,Godefroy Jacquemin

Correspondence Authors:
Hélène Authier

All Authors:
Mouna Rahabi,Godefroy Jacquemin,Mélissa Prat,Etienne Meunier,Mohamad AlaEddine,Bénédicte Bertrand,Lise Lefèvre,Khaddouj Benmoussa,Philippe Batigne,Agnès Aubouy,Johan Auwerx,Sylvain Kirzin,Delphine Bonnet,Marie Danjoux,Bernard Pipy,Laurent Alric,Hélène Authier,Agnès Coste