Symptoms of GERD Linked to COPD Exacerbation
NEW YORK (Reuters Health) Nov 26 - Results of a study published in the November issue of Thorax suggest that symptoms of gastroesophageal reflux disease (GERD) are an important factor associated with exacerbations in chronic obstructive pulmonary disease (COPD).
Dr. S. Muro of Kyoto University, Japan, and colleagues prospectively examined the association between GERD symptoms and COPD exacerbations in 82 patients with COPD and 40 age-matched controls over a 6-month period.
Overall, 22 COPD patients (26.8%) and five controls (12.5%) reported positive GERD symptoms. The incidence of COPD exacerbation was significantly higher in patients with GERD symptoms than in those without symptoms (relative risk 1.93; p < 0.01).
Results of multiple regression analysis revealed a significant association between GERD symptoms and the occurrence of exacerbations (RR 6.55; p < 0.01).
The authors report that the exhaled breath condensate (EBC) pH was inversely associated with the GERD symptom score in patients with COPD and in controls. However, EBC pH was not significantly correlated with COPD exacerbation frequency.
"It is difficult to determine whether (GERD) itself directly affects exacerbation or merely coexists in patients who experience frequent exacerbations," Dr. Muro's team comments. "Further examinations are needed to clarify whether treatment for (GERD) symptoms ameliorates COPD exacerbations."
Thorax 2008;63:951-955.
胃食管返流症状与慢性阻塞性肺病加重有关
（纽约路透电）11月26日-刊登在Thorax 11期的一份研究结果表明，胃食管返流（G ERD）症状是与慢性阻塞性肺疾病（COPD）加重有关的一个重要因素
日本京都大学S. Muro博士和同事们进行了一项为期6个月的前瞻性研究，观察82例慢性阻塞性肺病和40名年龄匹配的对照人群胃食管反流病症状和慢性阻塞性肺疾病加重之间的联系。
总的来说，22例COPD病人(26.8%)和5个对照组(12.5%)报告GERD症状阳性，有GERD症状患者的COPD加重发生率明显高于无GERD症状的患者（相对危险度1.93; p < 0.01）
多元回归分析结果显示胃食管反流病症状和加重发生率存在显著相关性(RR 6.55; p < 0.01).
报告指出，呼出气冷凝液(EBC) pH值与COPD患者和对照人群胃食管反流病症状评分负相关。然而， EBC pH值与COPD发作频率无显著相关性。
Muro博士的研究团队评论道 “尚难以确定那些频繁发作的患者，GERD本身直接影响发作频率抑或仅仅是合并症，进一步搞清治疗GERD是否减少COPD加重是必要的。” |
