看看你有没有肥胖基因

别惊讶，这是真的！现有研究表明，除了饮食和锻炼，肥胖由肥胖基因决定。

　　加州大学洛杉矶分校研究发现，相同情况下你的体重增加了而别人却没有，这可能是因为你们的基因存在差异。

　　饮食和锻炼仍是影响肥胖的最大因素。研究人员认为，基因在很大程度上决定了一个高脂肪饮食的人其体重增加的程度。

　　在本项研究中，研究员们研究了100只小鼠的基因，观察这些小鼠在8周时间内正常饮食情况，随后又观察这些小鼠在8周时间内高脂肪高糖的饮食情况。即使小鼠吃同样的食物，它们的体重也存在很大的差异。有的高脂肪饮食老鼠体内脂肪百分比没有变化，有的老鼠体内脂肪百分比却增加了600%。

　　这些差异很大程度上是遗传导致的。科学家识别并对比了老鼠基因中11个与肥胖和脂肪增加相关的区域，其中有几个区域跟人类的肥胖基因重叠。

　　首席研究员 Jake Lusis博士表明：“我们都见过那些吃很多但是不长胖的人。调查结果完全符合这一现象，基因对其有非常大的影响力”。

　　Lusis博士希望未来某一天，能研发出针对肥胖基因的药物和治疗方法。虽然这样的个性化医疗至少需要5到10年的时间，医生可以用成像技术使病人的代谢或者产生热量的褐色脂肪变得直观形象。

　　已有研究表明，肥胖有较高的遗传可能性。在后续的研究中，研究人员希望能够识别更多的“肥胖基因”并且测试这些基因是如何导致体重增加。

　　英文原文

　　“Fat Genes” Determine Obesity, UCLA Study Says, In Addition To Diet And Exercise

　　A new University of California Los Angeles study says you probably gained weight, and he didn't, because of a difference in your genes.

　　'If we understand how genetic factors influenced so much of the population to become obese, we could potentially reverse it with more research,' Dr. Parks said

　　In the study, UCLA researchers gave more than 100 genetic strains of mice a normal diet for eight weeks, followed by a high-fat, high-sugar diet for another eight weeks.

　　Even though the mice were eating the exact same diets, their weight gain varied greatly. The high-fat diet caused no change in body-fat percentage for some mice while others' body fat percentages increased by a whopping 600 percent.

　　Those differences were largely attributed to genetics. The scientists identified and compared 11 genetic regions associated with obesity and fat gain in the mice, several of which overlap with genes linked to obesity in humans.

　　The genetic differences translated into some mice being naturally more active and some being more effective at generating heat and thereby burning calories.

　　'We've all seen those people who eat a lot and don't gain weight. Our results are entirely consistent with that notion,' principal investigator Dr. Jake Lusis。 It isn’t just all about how much we eat. Genes had a huge effect.'

　　'If people consume a high-fat diet, the response will be predominantly determined by genetics,' Dr. Lusis said. 'But whether you choose to eat a high-fat diet in the first place is largely environmental.'While there have been numerous studies that have shown that obesity has high heritability, this is the first comprehensive study to examine whether response to a high-fat diet is genetic. Still, the researchers emphasized that environmental factors such as diet and exercise are also important to weight gain.

　　Dr. Brian Parks, study co-author and a postdoctoral researcher at the Geffen School of Medicine, told HuffPost that he hopes this and future research will lead to designing drugs and treatments that specifically target 'fat genes.'

　　And while that kind of personalized medicine is at least five to 10 years away, doctors soon be able to use imaging to visualize a patient's metabolism or 'brown fat,' which generates heat, Dr. Lusis said.

　　In follow-up studies, the researchers hope to identify more 'fat genes' and test the identified genes to understand how they're contributing to weight gain. The scientists also hope to understand the genetics of losing 。