总结 虽然β-内酰胺类抗菌药物所引起肝损伤较大环内酯类抗菌药物、抗结核药物、唑类抗真菌药物发生率较低,但是罕见的肝毒性不容忽视。 临床应规范抗菌药物的使用,加强对患者肝肾功能的监测,确保用药安全。 参考文献:[1]LiverTox:Clinical and Research Information on Drug-Induced Liver Injury[Internet].Bethesda(MD):National Institute of Diabetes and Digestive and Kidney Diseases;2012-.Cephalosporins,Oral.[Updated 2021 Dec 20].Available from:https://www.ncbi.nlm.nih.gov/books/NBK548358/[2]LiverTox:Clinical and Research Information on Drug-Induced Liver Injury[Internet].Bethesda(MD):National Institute of Diabetes and Digestive and Kidney Diseases;2012-.Cephalosporins,Parenteral.[Updated 2021 Dec 20].Available from:https://www.ncbi.nlm.nih.gov/books/NBK547862/[3]LiverTox:Clinical and Research Information on Drug-Induced Liver Injury[Internet].Bethesda(MD):National Institute of Diabetes and Digestive and Kidney Diseases;2012-.Ceftriaxone.[Updated 2021 Dec 20].Available from:https://www.ncbi.nlm.nih.gov/books/NBK548258/[4]LiverTox:Clinical and Research Information on Drug-Induced Liver Injury[Internet].Bethesda(MD):National Institute of Diabetes and Digestive and Kidney Diseases;2012-.Imipenem-Cilastatin.[Updated 2017 Jan 17].Available from:https://www.ncbi.nlm.nih.gov/books/NBK548708/[5]LiverTox:Clinical and Research Information on Drug-Induced Liver Injury[Internet].Bethesda(MD):National Institute of Diabetes and Digestive and Kidney Diseases;2012-.Meropenem.[Updated 2017 Jan 17].Available from:https://www.ncbi.nlm.nih.gov/books/NBK547861/