健康养生：MD anderson的研究:癌细胞可以感染周围的邻居细胞（把正常细胞变成癌细胞）（英文）

Cancer cell发表了MD Anderson Cancer Center in Houston, Texas的研究论文: 癌细胞可以感染周围的邻居细胞，把正常细胞变成癌细胞。研究发现癌细胞吐出来的microRNA可以感染周围的正常细胞，于是本来是好的邻居也变成坏蛋。读了真想

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原文链接: Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

抱歉，现在要付费阅读，过一段才会免费。


NatureNews上的介绍:

http://www.nature.com/news/cancer-cells-can-infect-normal-neighbours-1.16212?WT.mc_id=TWT_NatureNews
 

Dr Andrejs Liepins/Science Photo Library

A cancer cell (yellow) sheds membrane vesicles.

When a cancer cell throws out its trash, it can turn healthy neighbours into fellow tumour cells, researchers have found.

Many cells, including cancerous ones, shed thousands of tiny membrane-bound vesicles called exosomes that contain proteins, DNA and RNA. The process is thought to be a waste-management system, but it may also facilitate cell-to-cell communication: some of these vesicles can then merge with other cells and dump their payload inside.

In a study published online on 23 October in Cancer Cell¹, researchers show that when human breast-cancer exosomes can cause tumours when mixed with normal cells then injected into mice. The results could pave the way to finding markers to monitor the progression of cancer, and possibly even point to targets for therapies.

“It’s amazing — these vesicles were considered garbage cans,” says Khalid Al-Nedawi, a cancer researcher at McMaster University in Hamilton, Canada. “This paper really brings us closer to harnessing the potential of these tiny vesicles.”

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