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Nature医学：菌群与肠外器官的连接机制及影响（综述+长图）

Nature Medicine

2016-10-06Review 30.357影响因子

原标题：在生理机能和疾病中，从肠道菌群到远端器官的信号

① 肠道生态系统里数以万亿计的细菌形成一个生物反应器，由饮食中的营养素驱动并生成生物活性物质；② 代谢产物将信号传导到远端器官，使细菌与免疫和激素系统、大脑、宿主代谢及其他生理功能相连接；③ 微生物-宿主通讯对维持生理功能至关重要，菌群与肥胖、炎症性疾病、神经发育障碍有关生理异常等疾病相关；④ 本文系统介绍菌群-宿主相互作用及肠道菌群如何与肠外器官通讯，探讨这对宿主生理学的影响机制，及错误信号如何促成不同疾病。

2016-10-08 17:18 热心肠先生推荐

Title:

Signals from the gut microbiota to distant organs in physiology and disease

DOI:

10.1038/nm.4185

Abstract & Authors：展开 Abstract:

The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived metabolites signal to distant organs in the body, which enables the gut bacteria to connect to the immune and hormone system, to the brain (the gut-brain axis) and to host metabolism, as well as other functions of the host. This microbe-host communication is essential to maintain vital functions of the healthy host. Recently, however, the gut microbiota has been associated with a number of diseases, ranging from obesity and inflammatory diseases to behavioral and physiological abnormalities associated with neurodevelopmental disorders. In this Review, we will discuss microbiota-host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases.

All Authors:

Bjoern O Schroeder,Fredrik B?ckhed

First Authors:

Bjoern O Schroeder

Correspondence:

Fredrik B?ckhed

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关键词：

代谢产物 肥胖 自闭症 肠脑轴 肠肝轴 肠肺轴 信号传导