上海交大张晨虹：生酮饮食对糖脂代谢、肠道菌群及代谢产物的影响

生酮饮食引起小鼠葡萄糖不耐受和脂质积累，并改变其肠道菌群及代谢产物

10.1128/mBio.03601-20

03-30, Article

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The ketogenic diet (KD), which can induce changes in gut microbiota, has shown benefits for epilepsy and several neurodegenerative diseases. However, the effects of a KD on glucose and lipid metabolism remain inconclusive. Using two formulas of ketogenic diets (KDR with 89.5% fat and KDH with 91.3% fat), which are commonly used in mouse trials, we found that KDR but not KDH induced insulin resistance and damaged glucose homeostasis, while KDH induced more fat accumulation in mice. Further study showed that KD impacted glucose metabolism, which was related to the sources of fat, while both the sources and proportions of fat affected lipid metabolism. And the KD widely used in human studies still induced insulin resistance and fat accumulation in mice. Moreover, KDs changed the gut microbiota and metabolites in mice, and the sources and proportions of fat in the diets respectively changed the abundance of specific bacteria and metabolites which were correlated with parameters related to glucose intolerance and lipid accumulation. Overall, our study demonstrated that the metabolic disorders induced by KDs are closely related to the source and proportion of fat in the diet, which may be associated with the changes of the gut microbiota and metabolites.

First Authors:
Yue Li

Correspondence Authors:
Chenhong Zhang

All Authors:
Yue Li,Xin Yang,Jing Zhang,Tianyi Jiang,Ziyi Zhang,Zhiyi Wang,Mengxue Gong,Liping Zhao,Chenhong Zhang

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