“在拟南芥中，根时钟通过基因表达的振荡来调节侧生器官的间距。驱动根系时钟周期性的核心分子机制，以及它是如何被生长素和重力等外源信号修饰的，目前尚不清楚。
我们确定了振荡器的关键元件（AUXIN RESPONSE FACTOR 7、生长素敏感抑制剂IAA18/POTENT），它们在振荡区形成负调控环路。通过对实验数据的多层计算机模拟，我们解释了基因表达振荡如何与细胞分裂和生长相协调，从而形成器官间隔的周期性模式。此外，基于模型预测的重力模拟实验表明，外部生长素刺激可导致根钟的夹带。我们的工作证明了一个强大的生物钟背后的机制，以及它如何对外界刺激做出反应。”
Abstract: "In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the oscillator (AUXIN RESPONSE FACTOR 7, its auxin-sensitive inhibitor IAA18/POTENT, and auxin) that form a negative regulatory loop circuit in the oscillation zone. Through multilevel computer modeling fitted to experimental data, we explain how gene expression oscillations coordinate with cell division and growth to create the periodic pattern of organ spacing. Furthermore, gravistimulation experiments based on the model predictions show that external auxin stimuli can lead to entrainment of the root clock. Our work demonstrates the mechanism underlying a robust biological clock and how it can respond to external stimuli."
https://advances.sciencemag.org/content/7/1/eabd4722.full
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