国内团队：新冠肺炎患者的胃肠道及肝脏损伤（综述） | 热心肠日报

Signal Transduction and Targeted Therapy

[IF:13.493]

COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms

与COVID-19相关的胃肠道和肝脏损伤：临床特征和潜在机制

10.1038/s41392-020-00373-7

11-02, Review

Abstract & Authors:展开

Abstract:收起
Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as diarrhea, nausea, vomiting, and loss of appetite. SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2 (ACE2) and there is increasing evidence of a possible fecal–oral transmission route. In addition, there exist multiple abnormalities in liver enzymes. COVID-19-related liver injury may be due to drug-induced liver injury, systemic inflammatory reaction, and hypoxia–ischemia reperfusion injury. The direct toxic attack of SARS-CoV-2 on the liver is still questionable. This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19.

First Authors:
Peijie Zhong,Jing Xu,Dong Yang,Yue Shen,Lu Wang

Correspondence Authors:
Chaomin Wu,Xianglin Hu,Yangbai Sun

All Authors:
Peijie Zhong,Jing Xu,Dong Yang,Yue Shen,Lu Wang,Yun Feng,Chunling Du,Yuanlin Song,Chaomin Wu,Xianglin Hu,Yangbai Sun