肺纯毛玻璃影（pure GGO）

最近总结了20篇关于纯毛玻璃影的文献，有几个模糊不清的概念与大家探讨一下。

1、肺纯毛玻璃影所对应的病理是什么？

直径在1cm以下的纯毛玻璃影主要是原位癌（AIS）和微浸润癌（MIA）, 直径1-2cm之间的浸润性腺癌（MIA），逐渐增多，超过2cm的纯毛玻璃影，很少见，一般都会出现实性成分，绝大多数超过2cm的纯毛玻璃影为浸润性腺癌。

2、肺纯毛玻璃影预后如何？

20篇文献中100%的患者没有复发（norecurrence）。

3、肺纯毛玻璃影的手术方式和预后关系？

20篇文献，手术方式包括叶切，段切，楔切，没有一例复发，淋巴结清扫没有一例发生转移。

附上此20篇参考文献，供有兴趣的同道共同参阅：

[1]. Moon, Y., et al., Pure ground-glass opacity on chest computed tomography: predictive factors for invasive adenocarcinoma. J Thorac Dis, 2016. 8(7): p. 1561-70.

 [2]. Si, M.J., et al., Thin-section computed tomography-histopathologic comparisons of pulmonary focal interstitial fibrosis, atypical adenomatous hyperplasia, adenocarcinoma in situ,  and minimally invasive adenocarcinoma with pure ground-glass opacity. Eur J Radiol, 2016. 85(10): p. 1708-1715.

 [3]. Tamura, T. and H. Satoh, Quantitative CT Scanning Analysis of Pure Ground-Glass Opacity Nodules Predicts Further CT Change. Chest, 2016. 149(6): p. 1586-7.

 [4]. Cho, H. and H.Y. Lee, Is preoperative positron emission tomography-computed tomography a useful diagnostic or staging tool for pure ground glass opacity nodular adenocardinomas? J Thorac Cardiovasc Surg, 2016. 151(1): p. 280-1.

 [5]. Bak, S.H., et al., Quantitative CT Scanning Analysis of Pure Ground-Glass Opacity Nodules Predicts Further CT Scanning Change. Chest, 2016. 149(1): p. 180-91.

 [6]. Yamaguchi, M., et al., How should we manage small focal pure ground-glass opacity nodules on high-resolution computed tomography? A single institute experience. Surg Oncol, 2015. 24(3): p. 258-63.

 [7]. Kim, K.Y., et al., Cryoablation of a small pulmonary nodule with pure ground-glass opacity: a case report. Korean J Radiol, 2015. 16(3): p. 657-61.

 [8]. Liu, L.H., et al., CT findings of persistent pure ground glass opacity: can we predict the invasiveness? Asian Pac J Cancer Prev, 2015. 16(5): p. 1925-8.

 [9]. Jin, X., et al., CT characteristics and pathological implications of early stage (T1N0M0) lung adenocarcinoma with pure ground-glass opacity. Eur Radiol, 2015. 25(9): p. 2532-40.

[10]. Sakaguchi, Y., et al., A resected case of solitary pulmonary capillary hemangioma showing pure ground glass opacity. Ann Thorac Cardiovasc Surg, 2014. 20 Suppl: p. 578-81.

[11]. Chavez, C., et al., Image-guided bronchoscopy for histopathologic diagnosis of pure ground glass opacity: a case report. J Thorac Dis, 2014. 6(6): p. E81-4.

[12]. Lee, H.Y., et al., Pure ground-glass opacity neoplastic lung nodules: histopathology, imaging, and management. AJR Am J Roentgenol, 2014. 202(3): p. W224-33.

[13]. Chang, B., et al., Natural history of pure ground-glass opacity lung nodules detected by low-dose CT scan. Chest, 2013. 143(1): p. 172-178.

[14]. Cho, S., et al., Pathology and prognosis of persistent stable pure ground-glass opacity nodules after surgical resection. Ann Thorac Surg, 2013. 96(4): p. 1190-5.

[15]. Dong, M., et al., [Lung adenocarcinoma in situ which CT showed single pure ground-glass opacity: a  case report and literature review]. Zhongguo Fei Ai Za Zhi, 2013. 16(8): p. 438-40.

[16]. Lim, H.J., et al., Persistent pure ground-glass opacity lung nodules >/= 10 mm in diameter at CT scan: histopathologic comparisons and prognostic implications. Chest, 2013. 144(4): p. 1291-1299.

[17]. Inoue, D., et al., CT fluoroscopy-guided cutting needle biopsy of focal pure ground-glass opacity lung lesions: diagnostic yield in 83 lesions. Eur J Radiol, 2012. 81(2): p. 354-9.

[18]. Kim, H.K., et al., Management of multiple pure ground-glass opacity lesions in patients with bronchioloalveolar carcinoma. J Thorac Oncol, 2010. 5(2): p. 206-10.

[19]. Tamiya, A., et al., [A case of a pure ground glass opacity changing into advanced lung cancer confirmed by computed tomography]. Nihon Kokyuki Gakkai Zasshi, 2008. 46(7): p. 570-3.

[20]. Ohtsuka, T., et al., A clinicopathological study of resected pulmonary nodules with focal pure ground-glass opacity. Eur J Cardiothorac Surg, 2006. 30(1): p. 160-3.