*仅供医学专业人士阅读参考
寻常痤疮是以毛囊皮脂腺单位的炎症过程为特征的疾病,会影响80%~90%的青少年。
严重的痤疮炎症可导致遗留红斑或色素沉着,甚至永久性的痤疮瘢痕。
与活动性痤疮或痤疮后瘢痕相比,痤疮后红斑也称炎症后红斑(post-inflammatory ery-thema,PIE),是一种研究不足的痤疮后遗症,其临床意义常被低估[1]。
对于恼人的红痘印,今天跟大家盘点一下文献中的前沿治疗方法。
氨甲环酸
氨甲环酸(TXA)通过抑制促炎细胞素(IL-6和TNF-α)和新生血管形成来减少红斑,已被用于治疗红斑型玫瑰痤疮。
噻吗洛尔
图2. 马来酸噻吗洛尔治疗前后对比(图源参考文献)
羟甲唑林
他克莫司
图3. 他克莫司软膏治疗前后对比(图源参考文献)
联合制剂
染料激光(PDL)
Nd:YAG激光
强脉冲光(IPL)
图5. IPL 治疗前后对比(图源参考文献)
射频
皮秒激光
图7. 皮秒激光治疗前后对比(图源参考文献)
参考文献:
[1]朱学娥,向芳,段曼曼等.微针射频与强脉冲激光治疗痤疮后红斑的疗效比较[J].中国激光医学杂志,2023,32(01):48-50.
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[7]Yoon HJ, Lee DH, Kim SO, et,al. Acne erythema improvement by long-pulsed 595-nm pulsed-dye laser treatment: a pilot study. J Dermatolog Treat. 2008;19(1):38-44.
[8]Chalermsuwiwattanakan N, Rojhirunsakool S, Kamanamool N, et,al. The comparative study of efficacy between 1064-nm long-pulsed Nd:YAG laser and 595-nm pulsed dye laser for the treatment of acne vulgaris. J Cosmet Dermatol. 2021 Jul;20(7):2108-2115.
[9]Wu X, Wang X, Wu X, et,al. Intense Pulsed Light Therapy Improves Acne-Induced Post-inflammatory Erythema and Hyperpigmentation: A Retrospective Study in Chinese Patients. Dermatol Ther (Heidelb). 2022 May;12(5):1147-1156.
[10]Min S, Park SY, Yoon JY, et,al. Fractional Microneedling Radiofrequency Treatment for Acne-related Post-inflammatory Erythema. Acta Derm Venereol. 2016 Jan;96(1):87-91.
[11]Wen X, Li Y, Hamblin MR, Jiang X. A randomized split-face, investigator-blinded study of a picosecond Alexandrite laser for post-inflammatory erythema and acne scars. Dermatol Ther. 2020 Nov;33(6):e13941.
[12]Jia X, Zheng L, Fang L, Zhang L, Wu Y, Yang Y, Feng Y, Huang L. Evaluation of the safety and efficacy of a fractional picosecond 1064 nm laser for post-acne erythema in adult Chinese patients. Skin Res Technol. 2023 Jan;29(1):e13274.