参考文献[1]
BergheaEC, BalgradeanM, PopaIL.Correlation Between Idiopathic Nephrotic Syndrome and Atopy in Children － Short Review[J]．Maedica(Buchar)，2017，12(1):55-58.
[2]
DavinJC.
The glomerular permeability factors in idiopathic nephrotic syndrome[J]．
Pediatr Nephrol，
2016，
31(
2):
207-
215.
DOI：10.1007/s00467-015-3082-x.
[3]
KanaiT, ShiraishiH, YamagataT，et al.
Th2 cells predominate in idiopathic steroid－sensitive nephrotic syndrome[J]．
Clin Exp Nephrol，
2010，
14(
6):
578-
583.
DOI：10.1007/s10157-010-0330-z.
[4]
UwaezuokeSN.
Steroid－sensitive nephrotic syndrome in children：triggers of relapse and evolving hypotheses on pathogenesis[J]．
Ital J Pediatr，
2015，
41:
19.
DOI：10.1186/s13052-015-0123-9.
[5]
DongC．
Diversification of T－helper－cell lineages：finding the family root of IL－17－producing cells[J]．
Nat Rev Immunol，
2006，
6(
4):
329-
333.
DOI：10.1038/nri1807.
[6]
DongC．
TH17 cells in development：an updated view of their molecular identity and genetic programming[J]．
Nat Rev Immunol，
2008，
8(
5):
337-
348.
DOI：10.1038/nri2295.
[8]
ShaoXS, YangXQ, ZhaoXD，et al.
The prevalence of Th17 cells and FOXP3 regulate T cells(Treg) in children with primary nephrotic syndrome[J]．
Pediatr Nephrol，
2009，
24(
9):
1683-
1690.
DOI：10.1007/s00467-009-1194-x.
[9]
WeiCC, TsaiJD, LinCL，et al.
Increased risk of idiopathic nephrotic syndrome in children with atopic dermatitis[J]．
Pediatr Nephrol，
2014，
29(
11):
2157-
2163.
DOI：10.1007/s00467-014-2835-2.
[10]
Noval RivasM, CrotherTR, ArditiM．The microbiome in asthma[J]．Curr Opini Pediatr，2016，28(6):764-771.
[11]
Abdel－HafezM, ShimadaM, LeePY，et al.
Idiopathic nephrotic syndrome and atopy：is there a common link？[J]．
Am J Kidney Dis，
2009，
54(
5):
945-
953.
DOI：10.1053/j.ajkd.2009.03.019.
[12]
GandhiNA, PirozziG, GrahamNMH.
Commonality of the IL－4/IL－13 pathway in atopic diseases[J]．
Expert Rev Clin Immunol，
2017，
13(
5):
425-
437.
DOI：10.1080/1744666X.2017.1298443.
[13]
AkdisM, AkdisCA.
Mechanisms of allergen－specific immunotherapy：multiple suppressor factors at work in immune tolerance to allergens[J]．
J Allergy Clin Immunol，
2014，
133(
3):
621-
631.
DOI：10.1016/j.jaci.2013.12.1088.
[14]
Abdel－GadirA, MassoudAH, ChatilaTA.
Antigen－specific Treg cells in immunological tolerance：implications for allergic diseases[J]．
F1000Res，
2018，
7:
38.
DOI：10.12688/f1000research.12650.1.
[16]
KIML, van MeelER, Grosserichter－WagenerC，et al.
Associations of Th2，Th17，Treg cells，and IgA＋ memory B cells with atopic disease in children：The Generation R Study[J]．
Allergy，
2019.
DOI：10.1111/all.14010.Epub ahead of print.
[17]
FanconiG, KousmineC, FrischKW.Prognosis of the nephrosis syndrome[J]．Helv Paediatr Acta，1951，6(6):219-224.
[18]
HardwickeJ, SoothillJF, SquireJR，et al.
Nephrotic syndrome with pollen hypersensitivity[J]．
Lancet，
1959，
1(
7071):
500-
502.
DOI：10.1016/s0140-6736(59)91026-8.
[20]
RytandDA.Onset of the nephrotic syndrome during a reaction to bee sting[J]．Stanford Med Bull，1955，13(2):224-233.
[22]
ZellwegerF, EggelA．
IgE－associated allergic disorders：recent advances in etiology，diagnosis，and treatment[J]．
Allergy，
2016，
71(
12):
1652-
1661.
DOI：10.1111/all.13059.
[24]
LiuY, LaiM, LouY，et al.
Elevation of plasma－soluble HLA－G in childhood nephrotic syndrome is associated with IgE[J]．
Ann Clin Biochem，
2017，
54(
1):
69-
75.
DOI：10.1177/0004563216637625.
[25]
JahanI, HanifM, AliMA，et al.Relationship between serum IgE and frequent relapse idiopathic nephrotic syndrome[J]．Mymensingh Med J，2011，20(3):484-489.
[26]
FukeY, EndoM, OhsawaI，et al.
Implication of elevated serum IgE levels in minimal change nephrotic syndrome[J]．
Nephron，
2002，
91(
4):
769-
770.
DOI：10.1159/000065049.
[27]
StangouM, SpartalisΜ, DaikidouDV，et al.
Impact of Τh1 and Τh2 cytokines in the progression of idiopathic nephrotic syndrome due to focal segmental glomerulosclerosis and minimal change disease[J]．
J Nephropathol，
2017，
6(
3):
187-
195.
DOI：10.15171/jnp.2017.32.
[28]
CahenzliJ, BalmerML, McCoyKD.
Microbial－immune cross－talk and regulation of the immune system[J]．
Immunology，
2013，
138(
1):
12-
22.
DOI：10.1111/j.1365-2567.2012.03624.x.
[29]
KoolM, HammadH, LambrechtBN.
Cellular networks controlling Th2 polarization in allergy and immunity[J]．
F1000 Biol Rep，
2012，
4:
6.
DOI：10.3410/B4-6.
[30]
CoersW, VosJT, Van der MeidePH，et al.
Interferon－gamma(IFN－gamma) and IL－4 expressed during mercury－induced membranous nephropathy are toxic for cultured podocytes[J]．
Clin Exp Immunol，
1995，
102(
2):
297-
307.
DOI：10.1111/j.1365-2249.1995.tb03781.x.
[31]
YounYS, LimHH, LeeJH.
The clinical characteristics of steroid responsive nephrotic syndrome of children according to the serum immunoglobulin E levels and cytokines[J]．
Yonsei Med J，
2012，
53(
4):
715-
722.
DOI：10.3349/ymj.2012.53.4.715.
[32]
Al－EisaAA, AlRM, Al－AttiyahRJ.
Urinary excretion of IL－1β，IL－6 and IL－8 cytokines during relapse and remission of idiopathic nephrotic syndrome[J]．
J Inflamm Res，
2017，
10:
1-
5.
DOI：10.2147/JIR.S124947.
[33]
YoussefDM, ElbehidyRM, El－ShalAS，et al.T helper 1 and T helper 2 cytokines in atopic children with steroid－sensitive nephrotic syndrome[J]．Iran J Kidney Dis，2015，9(4):298-305.
[34]
ShalabySA, Al－EdressiHM, El－TarhounySA，et al.Type 1/type 2 cytokine serum levels and role of interleukin－18 in children with steroid－sensitive nephrotic syndrome[J]．Arab J Nephrol Transplant，2013，6(2):83-88.
[35]
KimuraA, NakaT, KishimotoT．
IL－6－dependent and －independent pathways in the development of interleukin 17－producing T helper cells[J]．
Proc Natl Acad Sci U S A，
2007，
104(
29):
12099-
12104.
DOI：10.1073/pnas.0705268104.
[36]
ArayaC, DiazL, WasserfallC，et al.
T regulatory cell function in idiopathic minimal lesion nephrotic syndrome[J]．
Pediatr Nephrol，
2009，
24(
9):
1691-
1698.
DOI：10.1007/s00467-009-1214-x.
[37]
WanF, LenardoMJ.
The nuclear signaling of NF－kappaB：current knowledge，new insights，and future perspectives[J]．
Cell Res，
2010，
20(
1):
24-
33.
DOI：10.1038/cr.2009.137.
[38]
LamaG, LuongoI, TirinoG，et al.
T－lymphocyte populations and cytokines in childhood nephrotic syndrome[J]．
Am J Kidney Dis，
2002，
39(
5):
958-
965.
DOI：10.1053/ajkd.2002.32769.
[39]
KanekoK, TsujiS, KimataT，et al.
Pathogenesis of childhood idiopathic nephrotic syndrome：a paradigm shift from T－cells to podocytes[J]．
World J Pediatr，
2015，
11(
1):
21-
28.
DOI：10.1007/s12519-015-0003-9.
[41]
WongratanacheewinS．Update of cytokines and genes in asthma and allergic rhinitis[J]．Asian Pac J Allergy Immunol，2014，32(4):275.
[42]
HanazawaT, AntuniJD, KharitonovSA，et al.
Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis[J]．
J Allergy Clin Immunol，
2000，
105(
1Pt 1):
58-
64.
DOI：10.1016/s0091-6749(00)90178-7.
[43]
BosséY, Rola－PleszczynskiM．
Controversy surrounding the increased expression of TGF beta 1 in asthma[J]．
Respir Res，
2007，
8:
66.
DOI：10.1186/1465-9921-8-66.
[44]
KariyawasamHH, GaneSB.
Allergen－induced asthma，chronic rhinosinusitis and transforming growth factor－β superfamily signaling：mechanisms and functional consequences[J]．
Expert Rev Clin Immunol，
2019，
15(
11):
1155-
1170.
DOI：10.1080/1744666X.2020.1672538.
[45]
ChenS, JinYT, ZhuZY，et al.
Acupoint application of herbal paste relieves symptoms and naso－mucosal inflammatory response by down－regulating serum TGF－β1 in allergic rhinitis rats[J]．
Zhen Ci Yan Jiu，
2019，
44(
6):
430-
433.
DOI：10.13702/j.1000-0607.180369.
[46]
XueJM, YangLT, YangG，et al.
Protease－activated receptor－2 suppresses interleukin(IL)－10 expression in B cells via upregulating Bcl2L12 in patients with allergic rhinitis[J]．
Allergy，
2017，
72(
11):
1704-
1712.
DOI：10.1111/all.13186.
[47]
JiangXG, YangXD, LvZ，et al.
Elevated serum levels of TNF－α，IL－8，and ECP can be involved in the development and progression of bronchial asthma[J]．
J Asthma，
2018，
55(
2):
111-
118.
DOI：10.1080/02770903.2017.1318141.
[48]
GittlerJK, ShemerA, Suárez－FariñasM，et al.
Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis[J]．
J Allergy Clin Immunol，
2012，
130(
6):
1344-
1354.
DOI：10.1016/j.jaci.2012.07.012.
[49]
ChanCY, NgKH, ChenJ，et al.
Novel role of Vav1－Rac1 pathway in actin cytoskeleton regulation in interleukin－13－induced minimal change－like nephropathy[J]．
Clin Sci(Lond)，
2016，
130(
24):
2317-
2327.
DOI：10.1042/CS20160312.
[50]
LaoukiliJ, PerretE, WillemsT，et al.
IL－13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells[J]．
J Clin Invest，
2001，
108(
12):
1817-
1824.
DOI：10.1172/JCI13557.
[51]
BagnascoD, FerrandoM, VarricchiG，et al.
A Critical Evaluation of Anti－IL－13 and Anti－IL－4 Strategies in Severe Asthma[J]．
Int Arch Allergy Immunol，
2016，
170(
2):
122-
131.
DOI：10.1159/000447692.
[52]
KimAH, ChungJJ, AkileshS，et al.
B cell－derived IL－4 acts on podocytes to induce proteinuria and foot process effacement[J]．
JCI Insight，
2017，
2(
21):
81836.
DOI：10.1172/jci.insight.81836.
[53]
ChaudhuriJN, GhosalSP.
Observations on prednisolone treated cases of nephrotic syndrome；a preliminary report[J]．
Indian J Pediatr，
1958，
25(
123):
201-
209.
DOI：10.1007/bf02903017.
[54]
BarbieriD．Early results of prednisone therapy of nephrotic syndromes[J]．Minerva Med，1955，46(99):1728-1733.
[55]
RadhakrishnanJ, CattranDC.
The KDIGO practice guideline on glomerulonephritis：reading between the(guide)lines－－application to the individual patient[J]．
Kidney Int，
2012，
82(
8):
840-
856.
DOI：10.1038/ki.2012.280.
[57]
LinCY, ChienJW.Increased interleukin－12 release from peripheral blood mononuclear cells in nephrotic phase of minimal change nephrotic syndrome[J]．Acta Paediatr Taiwan，2004，45(2):77-80.
[58]
SuyamaK, KawasakiY, MiyazakiK，et al.
Rituximab and low－dose cyclosporine combination therapy for steroid－resistant focal segmental glomerulosclerosis[J]．
Pediatr Int，
2016，
58(
3):
219-
223.
DOI：10.1111/ped.12804.
[59]
KallashM, SmoyerWE, MahanJD.
Rituximab Use in the Management of Childhood Nephrotic Syndrome[J]．
Front Pediatr，
2019，
7:
178.
DOI：10.3389/fped.2019.00178.
[61]
KhattriS, ShemerA, RozenblitM，et al.
Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology[J]．
J Allergy Clin Immunol，
2014，
133(
6):
1626-
1634.
DOI：10.1016/j.jaci.2014.03.003.
[62]
WollenbergA, BarbarotS, BieberT，et al.
Consensus－based European guidelines for treatment of atopic eczema(atopic dermatitis) in adults and children：part I[J]．
J Eur Acad Dermatol Venereol，
2018，
32(
5):
657-
682.
DOI：10.1111/jdv.14891.
[63]
WollenbergA, BarbarotS, BieberT，et al.
Consensus－based European guidelines for treatment of atopic eczema(atopic dermatitis) in adults and children：partII[J]．
J Eur Acad Dermatol Venereol，
2018，
32(
6):
850-
878.
DOI：10.1111/jdv.14888.
[64]
HotzeM, BaurechtH, RodríguezE，et al.
Increased efficacy of omalizumab in atopic dermatitis patients with wild－type filaggrin status and higher serum levels of phosphatidylcholines[J]．
Allergy，
2014，
69(
1):
132-
135.
DOI：10.1111/all.12234.
[65]
SimpsonEL, BieberT, Guttman－YasskyE，et al.
Two phase 3 trials of dupilumab versus placebo in atopic dermatitis[J]．
N Engl J Med，
2016，
375(
24):
2335-
2348.
DOI：10.1056/NEJMoa1610020.
[70]
PelaiaC, CalabreseC, TerraccianoR，et al.
Omalizumab，the first available antibody for biological treatment of severe asthma：more than a decade of real－life effectiveness[J]．
Ther Adv Respir Dis，
2018，
12:
1753466618810192.
DOI：10.1177/1753466618810192.
