平时我们介绍了很多数据库，今天把核酸研究（NAR）杂志上的一个总结列举出来：
红色的是我们已经介绍过的，有使用链接；蓝色的是今天要简单介绍的：
1. Descriptions of new online databasesin the 2019 NAR Database issue
DatabaseURLBrief description
AleDBhttp://aledb.orgMutations from Adaptive Laboratory Evolution experiments
AlloMAPShttp://allomaps.bii.a-star.edu.sgAllosteric signaling and mutations in proteins
AmtDBhttps://amtdb.orgAncient mitochondrial DNA
Ancestral Genomeshttp://ancestralgenomes.orgReconstructed ancestral genomes
AWESOMEhttp://www.awesome-hust.comImpact of SNPs on post-translational modifications
Bactomehttps://bactome.helmholtz-hzi.deSequences, transcriptomes and phenotypes of clinical isolates of Pseudomonas auruginosa
CAGmhttp://www.cagmdb.orgCatalog of all germline microsatellites
CancerSEAhttp://biocc.hrbmu.edu.cn/CancerSEA
Cancer single-cell state atlas
推文：
扔一个肿瘤单细胞数据库，CancerSEA给你一批思路CancerSplicingQTLhttp://www.cancersplicingqtl-hust.comSplicing quantitative trait loci in cancer
CellMarkerhttp://biocc.hrbmu.edu.cn/CellMarker
Cell markers in human and mouse
推文：
很多人一直在问的：细胞标志物（Marker）数据库！Cell Model Passportshttps://cellmodelpassports.sanger.ac.ukHuman cancer cell models
ChIPprimersDBhttp://www.chipprimers.com
qPCR oligonucleotide primers for chromatin immunoprecipitation (ChIP)
推文:
如何快速获取验证过的ChIP-qPCR实验引物序列？CMAUPhttp://bidd2.nus.edu.sg/CMAUPCollective molecular activities of useful plants
CoevDBhttp://phylodb.unil.ch/CoevDBPairwise nucleotide coevolution
CRISPRlnchttp://crisprlnc.xtbg.ac.cn
Validated CRISPR/Cas9 sgRNAs for model organism lncRNAs
推文：
通过CRISPR对lncRNA进行敲除，sgRNA的序列如何获取？Cucurbit Genomics Databasehttp://cucurbitgenomics.orgGenomics of the Cucurbitaceae family
dbAMPhttp://csb.cse.yzu.edu.tw/dbAMPAntimicrobial peptide sequences, structures and properties
DSMNChttp://dsmnc.big.ac.cnDatabase of somatic mutations in normal cells
EDKhttp://bigd.big.ac.cn/edkEditome disease knowledgebase
EncoMPASShttps://encompass.ninds.nih.govEncyclopedia of membrane proteins analyzed by structure and symmetry.
EndoDBhttps://vibcancer.be/software-tools/endodbGene expression in endothelial cells
ENPDhttp://qinlab.sls.cuhk.edu.hk/ENPDEukaryotic nucleic acid binding proteins
ETCMhttp://www.ehbio.com/ETCMEncyclopedia of Traditional Chinese Medicine
EVmiRNAhttp://bioinfo.life.hust.edu.cn/EVmiRNA
miRNA in extracellular vesicles
推文：
如果你研究外泌体和miRNA，又缺思路，用这个数据库就对了！EWAS Atlashttp://bigd.big.ac.cn/ewasEpigenome-Wide Association Studies
EWASdbhttp://www.bioapp.org/ewasEpigenome-Wide Association Studies Atlas
FusionGDBhttps://ccsm.uth.edu/FusionGDBFusion Gene annotation DataBase
gcMetahttps://gcmeta.wdcm.orgMicrobiome research data
Genome Propertieshttps://www.ebi.ac.uk/interpro/genomepropertiesPathways and other properties represented by sets of protein families
HACERhttp://bioinfo.vanderbilt.edu/AE/HACERHuman ACtive Enhancer to interpret Regulatory variants
HmtVarhttps://www.hmtvar.uniba.itHuman mitochondrial DNA variants
iDOGhttp://bigd.big.ac.cn/idogDog data on genes, SNPs, diseases etc.
iProXhttp://www.iprox.orgProteomics datasets
jPOSTdbhttps://jpostdb.orgJapan ProteOme STandard environment
KinaMetrixhttp://kinametrix.comProtein kinase models, conformations and ligands
liqDBhttp://bioinfo5.ugr.es/liqdbSmall RNA expression profiles in biofluids
LncBookhttp://bigd.big.ac.cn/lncbookHuman lncRNA knowledgebase
MemProtMDhttp://memprotmd.bioch.ox.ac.ukMembrane Proteins Embedded in Lipid Bilayers
MethMotifhttp://bioinfo-csi.nus.edu.sg/methmotifTranscription factor binding motifs coupled with DNA methylation profiles
NucMaphttp://bigd.big.ac.cn/NucMapNucleosome positioning map across species
OncoBasehttp://www.oncobase.biols.ac.cnRegulatory somatic mutations in human cancers
OpenProthttp://www.openprot.orgEukaryotic coding potential and proteomes
Pancan-meQTLhttp://bioinfo.life.hust.edu.cn/Pancan-meQTLMethylation quantitative trait loci in cancer
PDX Finderhttp://www.pdxfinder.orgPatient-derived xenograft models
PEDhttp://bigd.big.ac.cn/pedPlant Editosome Database
PreMedKBhttp://fudan-pgx.org/premedkbPrecision medicine knowledgebase
piRTarBasehttp://cosbi5.ee.ncku.edu.tw/piRTarBase
piRNA targeting sites
Plasmid Atlashttp://www.patlas.sitePlasmid annotations and metadata
PLSDBhttps://ccb-microbe.cs.uni-saarland.de/plsdbPlasmid annotations and metadata
PopHumanScanhttps://pophumanscan.uab.catPositively selected regions of the human genome
qPhoshttp://qphos.cancerbio.info
Protein phosphorylation dynamics
推文：
研究蛋白磷酸化，这个数据库你知道吗？RetroRuleshttp://retrorules.orgReaction rules for synthetic biology
RNacthttp://rnact.crg.euExperimental and predicted protein–RNA interactions in human and mouse
SAGDhttp://bioinfo.life.hust.edu.cn/SAGDSex-associated gene database
SEdbhttp://www.licpathway.net/sedb
Super-enhancer database
推文：
SEdb：一个“超级”全面的人类超级增强子数据库SSRomehttp://mggm-lab.easyomics.orgMicrosatellites in all organisms
SymMaphttp://www.symmap.orgTraditional chinese medicine including symptom mapping
Translocatomehttp://translocatome.linkgroup.huTranslocating human proteins
Trips-Vizhttp://trips.ucc.ieTranscriptome browser
UniLectinhttp://www.unilectin.euLectin structure and function
ViBrism DBhttps://vibrism.neuroinf.jpTomographic transcriptome and co-expression networks in mouse brain
Victorshttp://www.phidias.us/victorsVirulence factors
VMHhttp://vmh.lifeVirtual metabolic human
YeastRGBhttp://www.yeastRGB.orgExpression and localization of yeast proteins
2. Updated descriptions of databases most recently published elsewhere
DatabaseURLBrief description
CADDhttp://cadd.gs.washington.eduCombined annotation-dependent depletion
GENCODEhttp://www.gencodegenes.orgReference annotation for the human and mouse genomes.
glycosciences.DBhttp://www.glycosciences.de/databaseGlyco-related databases
Haemopediahttp://haemosphere.orgHaematopoietic expression data
HumanNethttps://www.inetbio.org/humannetHuman gene functional network
LncACTdbhttp://www.bio-bigdata.net/LncACTdblncRNA–miRNA–gene interactions
MoonDBhttp://moondb.hb.univ-amu.frKnown and predicted multifunctional proteins in model organisms
OrthoInspectorhttp://lbgi.fr/orthoinspectorv3Orthologous relations and phylogenetic profiling
piRBasehttp://www.regulatoryrna.org
piRNA function and annotation
推文：
只知miRNA，不知piRNA？那就从这个数据库开始吧！Stemformaticshttp://stemformatics.orgStem cell and other cell-specific gene expression
UNITEhttps://unite.ut.eeInternal transcribed spacer sequences for fungal identification
Vesiclepediahttp://www.microvesicles.org
Extracellular vesicles
推文：
(工具篇)S5E46：神器之——外泌体数据库大揭秘！下面我们挑几个部分蓝色的数据库做介绍：
1. AWESOME（SNP对翻译后修饰的影响）
http://www.awesome-hust.com
从核酸水平的基因多态性到蛋白水平的翻译后修饰：
展示结果包括了：磷酸化、泛素化、苏木化、糖基化等：
2.ETCM （中药数据库）
http://www.ehbio.com/ETCM
我们可以看到这里有单味药、也有复方、成分、靶点和疾病等，我们以黄芪为例：
可以看到比较详细的成分：
靶点、疾病和复方：
产地：
靶基因的功能注释：
以及network：
3. ENPD(真核生物核酸结合蛋白)
http://qinlab.sls.cuhk.edu.hk/ENPD
我们可以查看DNA/RNA结合蛋白的信息，比如转录因子和RBPs：
以YBX1为例：
不仅可以看到YBX1的序列：
还有结合的DNA与RNA基序特征：
