序号 名 字 位 置建设时间 说 明
1Virology Laboratory of the Queensland Department of HealthAustralia, Queensland, Coopers Plains
2Korea Centers for Disease Control and Prevention (KCDC)Osong, Cheongwon county, North Chungcheong province, South Korea2013
3University of Queensland - Sir Albert Sakzewski Virus Research Centre (SASVRC) Royal Women's Hospital Brisbane P3 (BL3)Australia, Queensland, Herston
4Australian Animal Health LaboratoryAustralia, Victoria, Geelong
5National High Security LaboratoryAustralia, Victoria, North Melbourne
National High Security Laboratory Operates under the auspice of the Victoria Infectious Diseases Reference Laboratory.
6Republican Research and Practical Center for Epidemiology and MicrobiologyBelarus, Minsk
Department of Molecular Epidemiology & Innovational Biotechnologies
7National Microbiology LaboratoryCanada, Manitoba, Winnipeg
Located at the Canadian Science Centre for Human and Animal Health, it is jointly operated by the Public Health Agency of Canada and the Canadian Food Inspection Agency.
8Wuhan Institute of Virology of the Chinese Academy of SciencesChina, Hubei, Wuhan2003Wuhan Institute of Virology already hosts a BSL-3 laboratory. A distinct BSL-4 facility is currently being built based on P4 standards, the original technology for confinement developed by France. It will be the first at level 4 in China, under the direction of Shi Zhengli.
9Biological Defense CenterCzech Republic, Pardubice, Těchonín1971, rebuilt 2003-2007Located at the Centrum biologické ochrany (Biological Defense Center)[13]
10Laboratoire P4 Jean MérieuxFrance, Rhône-Alpes, Lyon######Jean Mérieux laboratory is a co-operation between the Pasteur Institute and INSERM. Note that in France, it is P4 for Pathogen or Protection level 4.
11Centre International de Recherches Médicales de FrancevilleGabon
This facility is operated by a research organization supported by both Gabonese (mainly) and French governments, and is West Africa's only P4 lab (BSL-4).
12Robert Koch InstituteGermany, Berlin
The facility was licenced for construction by City of Berlin on November 30, 2008.
13Bernhard Nocht Institute for Tropical MedicineGermany, Hamburg
14Friedrich Loeffler Institute on the Isle of RiemsGermany, Isle of Riems (Greifswald)2010Deals especially with virology
15Philipps University of MarburgGermany, Marburg2008The facility is licenced to work with genetically modified organisms
16High Security Animal Disease Laboratory (HSADL)India, Bhopal1998This facility deals especially to zoonotic organisms and emerging infectious disease threats.
17Centre for Cellular and Molecular BiologyIndia, Hyderabad2009National Bio-Safety Level-4 Containment Facility for Human Infectious Diseases & Clinical Research Facility in Regenerative Medicine.
18All India Institute of Medical SciencesIndia, New Delhi1993Conducts studies on major pathogenic organisms. Has contributed in discovering new strains & vaccines.
19Microbial Containment ComplexIndia, Pune2012Bio-Safety Level-IV Laboratory established by ICMR with support from Department of Science & Technology
20Azienda Ospedaliera Ospedale Luigi SaccoItaly, Lombardy, Milan
A university hospital in Polo Universitario; it contains two special vehicles for transporting infectious persons.
21Istituto Nazionale Malattie InfettiveItaly, Lazio, Rome
This facility, (trans.) National Institute of Infectious Diseases, operates within the Lazzaro Spallanzani Hospital.
22National Institute for Infectious DiseasesJapan, Tokyo, Musashimurayama
Located at National Institute for Infectious Diseases, Department of Virology I; this lab has the potential of operating as a BSL-4, however it is limited to perform work on only BSL-3 agents due to opposition from local residents and communities.
23Institute of Physical and Chemical ResearchJapan, Ibaraki, Tsukuba
This is a non-operating BSL-4 facility.
24Netherlands National Institute for Public Health and the Environment (RIVM)Netherlands, Bilthoven2009
25Cantacuzino Microbiological Research Institute (INCDMI)Romania, Bucharest
26'Dr. Carol Davila' Central Military HospitalRomania, Bucharest
27State Research Center of Virology and Biotechnology VECTORRussia, Novosibirsk Oblast, Koltsovo
It is one of two facilities in the world that officially hold smallpox. The other Russian BSL-4 facilities have been dismantled.
28National Institute for Communicable DiseasesSouth Africa, Johannesburg
National Institute for Communicable Diseases of Special Pathogens Unit is one of only two BSL-4 facilities in Africa but the only suit laboratory on the continent.
29Swedish Institute for Communicable Disease ControlSweden, Solna
Swedish Institute for Communicable Disease Control is Scandinavia's P4 facility.
30University Hospital of GenevaSwitzerland
31Spiez LaboratorySwitzerland, Spiez
32Kwen-yang Laboratory (昆陽實驗室) Center of Disease ControlTaiwan
Part of the Department of Health, Taiwan.
33Preventive Medical Institute of ROC Ministry of National DefenseTaiwan
34Health Protection Agency's Centre for InfectionsUnited Kingdom, Colindale
Located in the Viral Zoonosis unit.
35National Institute for Medical ResearchUnited Kingdom, London
36Institute for Animal HealthUnited Kingdom, Pirbright
37Institute for Animal Health Compton LaboratoryUnited Kingdom, Compton
38Defence Science and Technology LaboratoryUnited Kingdom, Porton Down
39Health Protection AgencyUnited Kingdom, Porton Down
Special Pathogens Reference Unit.
40Health Protection AgencyUnited Kingdom, Porton Down
Botulism.
41Francis Crick Institute[22]United Kingdom, London
Under construction. The UKCMRI will not work on Human Hazard Group 4 agents.
42Centers for Disease Control and PreventionUnited States, Georgia, Atlanta
Currently operates in two buildings. One of two facilities in the world that officially hold smallpox.
43Georgia State UniversityUnited States, Georgia, Atlanta
Is an older design 'glovebox' facility.
44National Bio and Agro-Defense Facility (NBAF), Kansas State UniversityUnited States, Kansas, Manhattan
Under construction. Facility to be operated by the Department of Homeland Security, and replace the Plum Island Animal Disease Center (which is not a BSL-4 facility). Planned to be operational by 2015, but likely delayed.
45National Institutes of Health (NIH)United States, Maryland, Bethesda
Located on the NIH Campus, it currently only operates with BSL-3 agents.
46Integrated Research FacilityUnited States, Maryland, Fort Detrick
Under construction. This facility will be operated by National Institute of Allergy and Infectious Diseases (NIAID), it is planned to begin operating at 2009 at the earliest.
47National Biodefense Analysis and Countermeasures Center (NBACC)United States, Maryland, Fort Detrick
Under construction, it will be operated for the Department of Homeland Security.
48US Army Medical Research Institute of Infectious Diseases (USAMRIID)United States, Maryland, Fort Detrick1969Old building
49US Army Medical Research Institute of Infectious Diseases (USAMRIID)United States, Maryland, Fort Detrick2017?New building, currently under construction
50National Emerging Infectious Diseases Laboratory (NEIDL), Boston UniversityUnited States, Massachusetts, Boston
Under construction by Boston University, building and staff training complete, waiting for regulatory approval.
51NIAID Rocky Mountain LaboratoriesUnited States, Montana, Hamilton
National Institute of Allergy and Infectious Diseases
52Kent State University, Kent CampusUnited States, Ohio, Kent
Operates as a clean lab at level 3 for training purposes. Scheduled for conversion to a hot level 4 lab in response to a bioterrorism event in the USA.
53Galveston National Laboratory, National Biocontainment FacilityUnited States, Texas, Galveston
Opened in 2008, facility is operated by the University of Texas Medical Branch.[23]
54Shope LaboratoryUnited States, Texas, Galveston
Operated by the University of Texas Medical Branch (UTMB).
55Texas Biomedical Research InstituteUnited States, Texas, San Antonio
The only privately owned BSL-4 lab in the US.
56Division of Consolidated Laboratory ServicesUnited States, Virginia, Richmond
This facility is part of the Department of General Services of the Commonwealth of Virginia. so called 'surge' BSL-4 capacity.
（表中内容参考http://en.wikipedia.org/wiki/Biosafety_level#Biosafety_level_4 制作）
如上表所示，这56个生物安全顶级实验室遍布世界五大洲，其中非洲大陆只有两个，分别位于南非和加蓬。单论国家而言，美国最多，有15个，其中包括一个正在建设中的、隶属军队的实验室，还包括一个归私人所有的P4实验室（位于Texas Biomedical Research Institute，德州生物医学研究所），该P4实验室的私人属性（而非归国家所有）恐怕不仅在美国绝无仅有，恐怕在世界范围内都是独一无二的。
从上表可以看出，中国唯一的一个P4实验室，位于中科院病毒所。仅仅这一个独苗，目前尚且没有建成，俗话说“十年磨一剑”，但是这个“剑”已经磨了11年目前还不知何时才能正式磨成。根据《第一财经日报》的报道，“这个中国第一个也是唯一一个P4实验室，前期基础建设投入约2亿。……武汉P4实验室目前还没有建成，硬件和软件方面都需要推进。…….如果顺利的话，到今年年底会有一个阶段性的成果，但是距离能够使用还有一段距离。”（参考：http://tech.sina.com.cn/d/2014-08-06/01449537048.shtml）现在的埃博拉疫情相信会推动该实验室的建设速度。从报道和上表的内容可以看出，中国目前尚没有独立设计、建设P4实验室的能力，核心技术采用的是法国的。
值得一提的是，中国目前人口全球第一、GDP和研发经费全球第二，但是居然连一个已经建成使用的P4实验室都没有，应该说这在国际上都是很…、说不过去的事情，穷如非洲的加蓬都有一个（当然这个也是由法国援建和参与管理的），连经济和总体科技水平都不如中国的印度都有4个P4实验室，即使是被许多人贬称为弹丸之地的中国台湾都有2个P4实验室，当然虽然我们都政治正确地说是中国台湾,人家的两个实验室其实和中国大陆没有半毛钱关系，自己根本用不上。
需要说明的是, 除了埃博拉病毒必须要在P4实验室操作外，还有其他一些高致病性病毒，如马尔堡病毒，拉萨（Lassa）病毒, 克里米亚- 刚果出血热病毒, 玻利维亚和阿根廷出血热病毒以及其它出血热病毒等。
