参考文献[1]中华医学会骨科分会关节外科学组,中国医师协会骨科医师分会骨关节炎学组,国家老年疾病临床医学研究中心(湘雅医院),中华骨科杂志编辑部. 中国骨关节炎诊疗指南(2021年版)[J]. 中华骨科杂志, 2021, 41(18): 1291-1314.[2]赵彦萍,林志国,林书典,等. 骨关节炎诊疗规范[J]. 中华内科杂志, 2022, 61(10): 1136-1143.[3]Huang C, Zhang Z, Chen Y, et al. Development and formulation of the classification criteria for osteoarthritis[J]. Ann Transl Med. 2020, 8(17):1068.[4]孙天祥. 怎样区分骨关节炎与类风湿关节炎[J]. 家庭生活指南:下旬刊. 2020, 3:139.[5]陈付彩. 骨关节炎与类风湿性关节炎的区别与联系[J]. 现代医学与健康研究. 2017, 1(8): 162.[6]徐斌,周明旺,李盛华,等. JAK/STAT信号通路在骨关节炎致病机制及治疗靶点的研究进展[J]. 中国疼痛医学杂志. 2022, 28(2): 125-129.[7]黄静,袁卫红. 骨关节炎诊治方法新进展[J]. 国际放射医学核医学杂志. 2014, 38(1): 64-67.[8]赵青松,李欢,徐鹏,等. 骨关节炎(OA)的发病机制研究现状[J]. 生物骨科材料与临床研究, 2022, 19(3): 77-85.[9]周泽浩,阎伟,李金松,等. 信号通路在骨关节炎发生中作用的研究进展[J]. 山东医院, 2022, 62(13): 91-94.[10]Mora JC, Przkora R, Cruz-Almeida Y. Knee osteoarthritis: pathophysiology and current treatment modalities[J]. J Pain Res. 2018, 11: 2189-2196. [11]Latourte A, Kloppenburg M, Richette P. Emerging pharmaceutical therapies for osteoarthritis[J]. Nat Rev Rheumatol. 2020, 16(12):673-688. [12]Grässel S, Muschter D. Recent advances in the treatment of osteoarthritis[J]. F1000Res. 2020, 9: F1000 Faculty Rev-325. [13]Abramoff B, Caldera FE. Osteoarthritis: Pathology, Diagnosis, and Treatment Options. Med Clin North Am. 2020 Mar;104(2):293-311.[14]周俊廷,蒋学阳,冯锋,等. 多靶点药物设计策略及其研究进展[J]. 2018, 53(12): 2012-2025. [15]Xu Y, Zhu Q, Song J, et al. Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis[J]. Mediators Inflamm. 2015, 2015:356040.[16]Ye Y, Liu M, Tang L, et al. Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis[J]. Arthritis Res Ther. 2019, 21(1):92.[17]Luo Q ,Sun Y, Liu W,et al. A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide[J].The Journal of Immunology. 2013, 191(10): 4969–4978.[18]M Kohno , Y Aikawa, Y Tsubouchi, et al. Inhibitory effect of T-614 on tumor necrosis factor-alpha induced cytokine production and nuclear factor-kappaB activation in cultured human synovial cells[J] .Journal of Rheumatology .2001, 28(12):2591-6.[19]Tateiwa D, Yoshikawa H, Kaito T. Cartilage and Bone Destruction in Arthritis: Pathogenesis and Treatment Strategy: A Literature Review. Cells. 2019, 8(8):818. [20]曾惠琼,罗国辉,卢小平,等. 艾拉莫德对膝骨关节炎的疗效及作用机制初探[J]. 中华生物医学工程杂志, 2019, 25(2): 216-219.[21]刘淑敏. 艾拉莫德治疗膝骨关节炎的临床疗效观察[J]. 中国保健营养, 2020, 30(9): 237-238.[22]Cong S, Meng Y, Wang L, et al. T-614 attenuates knee osteoarthritis via regulating Wnt/β-catenin signaling pathway[J]. J Orthop Surg Res. 2021, 16(1):403. 此文仅用于向医疗卫生专业人士提供科学信息,不代表平台立场。