维生素C或可代替锻炼来改善个体心血管健康

2015年9月9日 讯 /生物谷BIOON/ --过重和肥胖个体经常会被建议通过锻炼来改善机体健康，但有超过50%的个体似乎根本达不到这样的要求。近日，在举办的第14届内皮素：生理学、病理生理学及治疗学国际会议上，一项研究就指出，成年个体每天服用维生素C添加剂或许和有规律地锻炼一样可以带来相似的心血管效益。

过重及肥胖成年个体的血管中小型血管压缩蛋白内皮素-1（ET-1）的活性会升高，由于具有较高的ET-1活性，这些血管就更易于收缩，对血流量要求的敏感性降低，同时也会增加患心血管疾病的风险。而锻炼可以帮助降低ET-1的水平，但将锻炼的体系加入到每天的日程安排中对于每个人来说是一项巨大的挑战，这项研究由科罗拉多大学的科学家进行，研究者就检测了曾经被报道可以改善血管功能的维生素C补充剂是否可以降低ET-1的活性。

研究者发现，每日摄入500mg的维生素C补充剂或同锻炼的效果一样，可以减少ET-1相关的血管收缩，而维生素C补充剂似乎也可以作为一种有效的策略来帮助降低过重和肥胖成年个体机体中的ET-1介导的血管收缩。

最后，Caitlin Dow教授表示，我们发现维生素C补充剂可以有效降低过重和肥胖个体机体血管中ET-1系统的活性，这对于后期开发新型的锻炼替代疗法来改善个体的健康或将提供新的帮助。（生物谷Bioon.com）

本文系生物谷原创编译整理，欢迎转载！转载请注明来源并附原文链接。更多资讯请下载生物谷APP.

生物谷推荐的新闻阅读：

Vitamin C—the exercise replacement?

Overweight and obese adults are advised to exercise to improve their health, but more than 50 percent do not do so. New research to be presented at the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics suggests that taking vitamin C supplements daily can have similar cardiovascular benefits as regular exercise in these adults.

The blood vessels of overweight and obese adults have elevated activity of the small vessel-constricting protein endothelin (ET)-1. Because of the high ET-1 activity, these vessels are more prone to constricting, becoming less responsive to blood flow demand and increasing risk of developing vascular disease. Exercise has been shown to reduce ET-1 activity, but incorporating an exercise regimen into a daily routine can be challenging. This study, conducted at the University of Colorado, Boulder, examined whether vitamin C supplements, which have been reported to improve vessel function, can also lower ET-1 activity.

The researchers found that daily supplementation of vitamin C (500 mg/day, time-released) reduced ET-1-related vessel constriction as much as walking for exercise did. Vitamin C supplementation represents an effective lifestyle strategy for reducing ET-1-mediated vessel constriction in overweight and obese adults, the researchers wrote.

Caitlin Dow, PhD, postdoctoral research fellow at the University of Colorado, Boulder, will present "Vitamin C Supplementation Reduces ET-1 System Activity in Overweight and Obese Adults" at the poster session on Friday, September 4, from 1 to 2:30 PM in Ballroom BCDEF of the Hyatt Regency Savannah.