当然,截至目前上述研究只是体外小鼠试验的数据,CRAF抑制剂尚处于研发的早期。但上述研究依然给广大胰腺癌病友,带来了振奋人心的曙光。 参考文献: [1]. OverallSurvival in Patients With Pancreatic Cancer Receiving Matched TherapiesFollowing Molecular Profiling: A Retrospective Analysis of the Know Your TumorRegistry Trial. Lancet Oncol. 2020 Apr;21(4):508-518[2]. MaintenanceOlaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. N Engl J Med.2019 Jul 25;381(4):317-327[3]. CompleteRegression of Advanced Pancreatic Ductal Adenocarcinomas Upon CombinedInhibition of EGFR and C-RAF.CancerCell. 2019 Apr 15;35(4):573-587.e6. doi:10.1016/j.ccell.2019.03.002