Knoevenagel缩合反应

羰基化合物和活泼亚甲基化合物在胺催化下缩合的反应。

反应机理

胺作为碱对活泼亚甲基进行拔氢，得到碳负离子。另一分子的胺再和羰基化合物缩合得到亚胺离子。碳负离子进攻亚胺离子，脱掉胺，水解脱羰，得到产物。

反应实例

参考文献

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编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Knoevenagel condensation，page 329-330.