【晨读】短时程外周神经电刺激治疗老年眼神经带状疱疹神经痛患者:回顾性研究(二）

 英语晨读 ·

山东省立医院疼痛科英语晨读已经坚持10余年的时间了，每天交班前15分钟都会精选一篇英文文献进行阅读和翻译。一是可以保持工作后的英语阅读习惯，二是可以学习前沿的疼痛相关知识。我们会将晨读内容与大家分享，助力疼痛学习。

本次文献选自Wan C,Song T.Short-Term Peripheral Nerve Stimulation Relieve Pain for Elder Herpes Zoster Ophthalmicus Patients:A Retrospective Study[J].Neuromodulation,2020;E-pub ahead of print.

INTRODUCTION

Herpes zoster (HZ) ophthalmicus occurs when the latent herpes zoster virus are reactivated and spread from the ganglion of gasser to the ophthalmic nerve . It has been estimated that the inci-dence of HZ is 4–5 per 1000 patients, from which 10–20% cases are HZ ophthalmicus . The symptoms can be severe pain and a periocular cutaneous rash limited to the periorbital region . 

Postherpetic neuralgia (PHN) can be defined as neuropathic pain persisting more than six months after scar tissue formation. Older age is a vital factor associated with higher risk to develop to PHN . PHN is a refractory chronic pain syndrome with a complex cause and pathogenesis which is unclear by far, however, there was no effective treatments to cure it . Hence the prevention from HZ ophthalmicus to ophthalmic PHN in elder patients is an essential therapy strategy.

前言

当潜伏的带状疱疹病毒被重新激活并从神经节扩散到眼神经时，就会发生眼神经带状疱疹(HZ)。据统计，每1000名患者中有4 - 5名患者发生带状疱疹，其中10- 20%的患者是眼神经带状疱疹。症状可表现为局限于眼眶周围的皮肤皮疹的严重疼痛。

带状疱疹后神经痛(PHN)可以定义为疤痕组织形成后持续6个月以上的神经病理性疼痛。年龄越大，PHN发生的风险越大。PHN是一种病因复杂、发病机制尚不清楚的难治性慢性疼痛综合征。然而，没有有效的治疗方法来治愈它。因此，预防老年带状疱疹患者发展为带状疱疹后神经痛是重要的治疗策略。

Peripheral nerve stimulation (PNS) refers to implant a lead near the nerve to stimulate it directly . This technique has been used to treat intractable various pain, such as occipital neuralgia, cervicogenic headache, PHN, intractable cancer pain, and so on . Long-term PNS is one of the better treatments for ophthalmic PHN , but is it necessary for HZ ophthalmicus? In this study, we would investigate the efficacy of short-term PNS for elder HZ ophthalmicus patients in order to prevent its development to ophthalmic PHN.

周围神经刺激(Peripheral nerve stimulation, PNS)是指在神经附近植入一个电极，直接刺激神经。该技术已被用于治疗各种顽固性疼痛，如枕神经痛、颈源性头痛、PHN、顽固性癌症疼痛等。长时程PNS是治疗眼神经PHN的较好方法之一(15)，但对眼神经带状疱疹有必要吗?在本研究中，我们将探讨短时程PNS对老年眼神经带状疱疹性神经痛的疗效，以防止其发展为眼神经PHN。

参考文献：

【晨读】短时程外周神经电刺激治疗老年眼神经带状疱疹神经痛患者:回顾性研究(一）