目前HD治疗已能望及上限,治疗间隔、透析液需求大、治疗不便捷和高医疗成本等问题都实实在在困扰着像老李一样的患者。而便携式或者可穿戴式透析系统的开发,则是医学、工业、商业等多方面需要通力探索的领域。 总体来说,便携式或者可穿戴式设备的广泛使用依然存在诸多挑战,未来将如何解决呢? 或点击阅读原文,获取完整内容。 相信通过多方合作,医患研多方参与指导肾脏疾病创新、专业及监管机构推动创新和加速开发新技术等,RRT患者才会有更美好的明天。 参考文献:[1] Eknoyan G, Beck G J, Cheung A K, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis[J]. New England Journal of Medicine, 2002, 347(25): 2010-2019.[2] Paniagua R, Amato D, Vonesh E, et al. Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial[J]. Journal of the American Society of Nephrology, 2002, 13(5): 1307-1320.[3] Ramada D L, de Vries J, Vollenbroek J, et al. Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges[J]. Nature Reviews Nephrology, 2023: 1-10.[4] Humes H D, Weitzel W F, Bartlett R H, et al. Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure[J]. Kidney international, 2004, 66(4): 1578-1588.[5] Chevtchik N V, Mihajlovic M, Fedecostante M, et al. A bioartificial kidney device with polarized secretion of immune modulators[J]. Journal of tissue engineering and regenerative medicine, 2018, 12(7): 1670-1678.[6]Chevtchik N V, Fedecostante M, Jansen J, et al. Upscaling of a living membrane for bioartificial kidney device[J]. European journal of pharmacology, 2016, 790: 28-35.[7]Mihajlovic M, Fedecostante M, Oost M J, et al. Role of vitamin D in maintaining renal epithelial barrier function in uremic conditions[J]. International journal of molecular sciences, 2017, 18(12): 2531.[8] Caressa Chen et al. Demonstrating preclinical proof of concept of an implantable bioartificial kidney (iBAK). Abstract PO0513 ASN 2022 (2022).[9] Gura V, Rivara M B, Bieber S, et al. A wearable artificial kidney for patients with end-stage renal disease[J]. JCI insight, 2016, 1(8).[10] Davenport A, Gura V, Ronco C, et al. A wearable haemodialysis device for patients with end-stage renal failure: a pilot study[J]. The Lancet, 2007, 370(9604): 2005-2010.