“吃胍群众”注意啦！一图读懂升级版二甲双胍

强效降糖、一天一次、耐受性好，

这种良药的三大特点你读懂了吗？

参考文献：

【1】母义明，纪立农，宁光等.二甲双胍临床应用专家共识（2016年版）.中国糖尿病杂志.2016,24(10):871-884.

【2】Fujioka K, Brazg RL, Raz Iet al. Efficacy, dose-responserelationship and safety of once-daily extended-release metformin (GlucophageXR) in type 2 diabetic patients with inadequate glycaemic control despite priortreatment with diet and exercise: results from two double-blind,placebo-controlled studies. Diabetes Obes Metab.2005;7(1):28-39.

【3】吴燕，张春全，徐荣.不同厂家盐酸二甲双胍缓释片体外缓释度考察.安徽医药.2014.18(6):1050-1052.

【4】张丹，杨漫，韩静等.盐酸二甲双胍肠溶片上市后人体生物等效性再评价.中国药学杂志.2012,47(18):1565-1569.

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【7】Forslund K, et al. Disentangling type 2 diabetes and metformin treatmentsignatures in the human gut microbiota.Nature. 2015 Dec10;528(7581):262-266.

【8】Blonde L, Dailey GE, Jabbour SA et al.Gastrointestinal tolerability of extended-release metformin tablets compared toimmediate-release metformin tablets: results of a retrospective cohortstudy.Curr Med Res Opin.2004;20(4):565-72.