2021年度睡眠障碍重要研究进展

睡眠是一种高度保守的生命现象，与生物进化、物种繁衍和个体生存发展等密切相关。睡眠在正常生命活动及重大疾病发生中都发挥重要作用。2021年，睡眠医学有哪些新进展，有哪些新期待，让我们一起来学习吧。

图 1.睡眠剥夺影响炎症反应^[7]

图 2.睡眠与糖尿病相互影响^[10]

2.睡眠时长与心血管疾病

一项纳入404044人的研究发现，睡眠时长与高血压、房颤、肺栓塞和慢性缺血性心脏病呈负相关^[11]。提示睡眠时长过短（≤6小时）是高血压、房颤、肺栓塞和慢性缺血性心脏病的潜在风险因素（图3）。

图 3.睡眠时长与心血管疾病^[11]

图 4.睡眠障碍与多种精神疾病的关系

图 5.睡眠医学多学科交叉

参考资料：

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8.Gengatharan A,Malvaut S,Marymonchyk A,et al.Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics.Cell.2021;184(3):709-722.e13.

9.Krone LB,Yamagata T,Blanco-Duque C,et al.A role for the cortex in sleep-wake regulation.Nat Neurosci.2021;24(9):1210-1215.

10.Brzecka A,Madetko N,Nikolenko VN,et al.Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link.Curr Neuropharmacol.2021;19(1):78-91.

11.Ai S,Zhang J,Zhao G,et al.Causal associations of short and long sleep durations with 12 cardiovascular diseases:linear and nonlinear Mendelian randomization analyses in UK Biobank.Eur Heart J.2021;42(34):3349-3357.

12.Winer JR,Deters KD,Kennedy G,et al.Association of Short and Long Sleep Duration With Amyloid-βBurden and Cognition in Aging.JAMA Neurol.2021;78(10):1187-1196.

13.Insel PS,Mohlenhoff BS,Neylan TC,Krystal AD,Mackin RS.Association of Sleep andβ-Amyloid Pathology Among Older Cognitively Unimpaired Adults.JAMA Netw Open.2021;4(7):e2117573.

14.Wainberg M,Jones SE,Beaupre LM,et al.Association of accelerometer-derived sleep measures with lifetime psychiatric diagnoses:A cross-sectional study of 89,205 participants from the UK Biobank.PLoS Med.2021;18(10):e1003782.

15.Alkozei A,Dailey NS,Bajaj S,et al.Exposure to Blue Wavelength Light Is Associated With Increases in Bidirectional Amygdala-DLPFC Connectivity at Rest.Front Neurol.2021;12:625443.

16.Herrero Babiloni A,Bellemare A,Beetz G,et al.The effects of non-invasive brain stimulation on sleep disturbances among different neurological and neuropsychiatric conditions:A systematic review.Sleep Med Rev.2021;55:101381.

17.Wang J,Yang S,Li X,et al.Efficacy and safety of solriamfetol for excessive sleepiness in narcolepsy and obstructive sleep apnea:findings from randomized controlled trials.Sleep Med.2021;79:40-47.

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