Clinical features and outcomes of COVID-19 and dengue co-infection: a systematic review
作者：Tsheten Tsheten, Archie C. A. Clements, Darren J. Gray, Ripon K. Adhikary, Kinley Wangdi
期刊：BMC Infectious Diseases
发表时间：2021/08/02
Background
Dengue is the most common arboviral disease in the tropical and sub-tropical regions of the world. Like other regions, dengue-endemic areas have faced the additional public health and socio-economic impact of the ongoing coronavirus disease 2019 (COVID-19) pandemic. COVID-19 and dengue co-infections have been reported, with complicated patient management and care requirements. This review aimed to collate and synthesise current knowledge on the clinical features and outcomes of COVID-19 and dengue virus co-infection, a potentially important new dimension to be considered in public health management of the COVID-19 pandemic.
Methods
A systematic literature review was conducted using PubMed, Web of Science and Scopus databases from 1st January to 21st November 2020. The key search terms used were “dengue” and “coronavirus”. Descriptive analysis with graphical illustrations were used to present the clinical and laboratory parameters of the co-infection.
Results
Thirteen published papers and four news articles were included in the review. Most studies were case reports with a detailed description of the clinical and laboratory characteristics of the co-infection. All cases were in adults with the exception of a six-year old child. The common symptoms of co-infection were fever, dyspnea, headache, and cough. Common laboratory results included thrombocytopenia, lymphocytopenia, elevated transaminases, and leukopenia. Serious outcomes of co-infection included septic shock, acute respiratory disease syndrome and multi-organ failure, leading to death in some patients.
Conclusions
COVID-19 and dengue co-infection was associated with severe disease and fatal outcomes. The correct diagnosis and treatment of co-infection poses a substantial challenge due to the overlapping clinical and laboratory parameters. Therefore, confirmative diagnostic tests are necessary for accurate and timely diagnosis and patient management.
© CROCOTHERY / stock.adobe.com
新冠病毒（COVID-19）是由严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引起的严重呼吸道疾病。在COVID-19大流行期间，登革热病例数量也在增加。登革热是影响世界热带和亚热带地区居民最常见的虫媒病毒感染。据估计，全世界每年有9600万人感染登革热，2.1万人死亡。
SARS-CoV-2和登革热病毒的同时感染是一个严重的公共卫生问题，因为这两种疾病的临床和实验特征重叠，使得医生对这两种疾病的诊断与管理都很困难。尽管这两种疾病的体征和症状（如发热、头痛和身体疼痛）以及实验特征（如血小板和白细胞减少症）相似，但它们的治疗方式完全不同。因此，有必要使用RT-PCR或ELISA进行特异性检测，以确认这些疾病的诊断。
对SARS-CoV-2和登革热病毒合并感染的延误诊断可能会导致严重的患者并发症，且预后不良。Tsheten等人的系统综述强调了使用病毒特异性检测进行准确及时诊断的重要性。
原文链接：Highlights of the BMC Series: Aug 2021
本站仅提供存储服务，所有内容均由用户发布，如发现有害或侵权内容，请
点击举报。
