对于乳腺癌女性，通常推荐进行适当的体力活动。不过，早期乳腺癌女性体力活动水平、生活质量、术后内分泌辅助治疗所致症状之间的相关性尚不明确。
2020年7月2日，美国癌症学会《癌症》在线发表弗吉尼亚联邦大学和乔治城大学的女性内分泌治疗开始与坚持（WHIP）研究分析报告，调查了早期乳腺癌女性体力活动水平、健康相关生活质量、术后内分泌辅助治疗所致症状之间的相关性。
该前瞻队列研究于2014年8月20日～2014年10月28日从乔治城大学入组激素受体阳性乳腺癌术后内分泌辅助治疗期间黑人和白人女性485例，完成健康相关生活质量、内分泌辅助治疗所致症状、体力活动水平的标准化问卷调查。通过沃尔德卡方检验和方差分析，对体力活动与其他独立因素的关系进行评定。通过广义线性回归分析，对体力活动、生活质量、内分泌辅助治疗所致症状的关系进行评定。
结果，根据双因素分析，体力活动水平较低的相关因素包括：
黑人（与白人相比）
体重指数较高（与较低相比）
服用芳香化酶抑制剂（与他莫昔芬相比）
根据多因素分析，自己报告体力活动水平较低的独立相关因素包括：
体重指数较高（P=0.02）
化疗比例较高（P=0.006）
中等体力活动水平较高的堵独立路相关因素包括：
健康相关生活质量较好（P=0.01）
内分泌治疗所致严重症状较少（P=0.02）
内分泌治疗所致妇科症状较少（P=0.03）
因此，该研究结果表明，对于术后内分泌辅助治疗女性，适度体力活动可能减少药物所致症状、提高健康相关生活质量总体评分。由于整个样本观察到的体力活动水平总体较低，尤其黑人女性，故有必要确定哪些成功策略可以促进体力活动。
Cancer. 2020 Jul 2. Online ahead of print.
Physical activity, health-related quality of life, and adjuvant endocrine therapy-related symptoms in women with hormone receptor-positive breast cancer.
Sheppard VB, Dash C, Nomura S, Sutton AL, Franco RL, Lucas A, Ross M, Adams-Campbell L.
Virginia Commonwealth University, Richmond, Virginia; Georgetown University, Washington, DC.
Among women taking adjuvant endocrine therapy, moderate levels of physical activity may be associated with fewer medication-related symptoms and overall better ratings of health-related quality of life. Because of the low levels of physical activity observed in the sample overall and particularly for Black women, identifying successful strategies to promote physical activity are needed.
BACKGROUND: Physical activity (PA) is recommended for women with breast cancer (BC); however, data are sparse on the association of PA with quality of life (QOL) and patient-reported symptoms for women on adjuvant endocrine therapy (AET).
METHODS: Women with hormone receptor-positive BC who were taking AET completed standardized surveys about their health-related QOL, AET-related symptoms, and levels of PA using validated measures. A Wald chi-square test and an analysis of variance were used to assess associations with PA and independent variables. Generalized linear regression analyses assessed associations between PA, QOL, and AET-related symptoms.
RESULTS: The analytic cohort included 485 Black and White women. Black race, a high body mass index (BMI), and being on aromatase inhibitors (vs tamoxifen) were associated with lower PA in a bivariate analysis. In a multivariate analysis, lower self-reported PA was associated with a high BMI (P = .02) and chemotherapy uptake (P = .006). Better health-related QOL (P = .01), less severe overall AET-related symptoms (P = .02), and less severe gynecological symptoms (P = .03) were associated with increasing levels of moderate PA.
CONCLUSIONS: Among women taking AET, moderate levels of PA may be associated with fewer medication-related symptoms and overall better ratings of health-related QOL. Because of the low levels of PA observed in the sample overall and particularly for Black women, identifying successful strategies to promote PA are needed.
KEYWORDS: breast neoplasms; exercise; quality of life; therapeutics
PMID: 32614992
DOI: 10.1002/cncr.33054
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